Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362921 | 0.86 | KMT2A (0.46) | SMN1; SMN2ALDH1A1POLBL3MBTL1HTT | |
| SCHEMBL6744642 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL3253348 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL14725297 | 0.81 | POLB (0.44) | SMN1; SMN2POLBMAPTHSD17B10KMT2A | |
| SCHEMBL11214768 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL11214765 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL28085824 | 0.79 | NFE2L2 (0.50) | SMN1; SMN2ALDH1A1POLBGAALMNA | |
| SCHEMBL11556734 | 0.79 | PTPN1 (0.49) | SMN1; SMN2ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL29620411 | 0.77 | L3MBTL1 (0.58) | SMN1; SMN2ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL1327130 | 0.77 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1POLBL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |
| US-4818772-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | SOCIETE CORTIAL S.A. (FR) | 1989-04-04 | — | — | US | disclosed |