SCHEMBL9505658

SCHEMBL9505658

Ic1cccc2c1CCC2

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.50
BAD Q92934 1/20 0.50
TSHR P16473 3/20 0.42
SIGMAR1 Q99720 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
KDM4E B2RXH2 1/20 0.37
NISCH Q9Y2I1 1/20 0.37
ALDH1A1 P00352 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP2A6 P11509 1/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30531772 0.95 BCL2L1 (0.56) BCL2L1BADTSHRSIGMAR1L3MBTL1
SCHEMBL8384556 0.95 BCL2L1 (0.56) BCL2L1BADTSHRSIGMAR1L3MBTL1
SCHEMBL22493786 0.85
SCHEMBL23333489 0.77 HTR2C (0.37) BCL2L1BADTSHR
SCHEMBL20880753 0.76 HTR2C (0.54) MAOB
SCHEMBL11327500 0.76 PNMT (0.50) MAOB
SCHEMBL17698887 0.75 BCL2L1 (0.54) BCL2L1BADTSHRSIGMAR1L3MBTL1
SCHEMBL29488244 0.75 BCL2L1 (0.54) BCL2L1BADTSHRSIGMAR1L3MBTL1
SCHEMBL19711056 0.74 PNMT (0.47) BCL2L1BADKDM4EMEN1KMT2A
SCHEMBL2778545 0.73 BCL2L1 (0.52) BCL2L1BADTSHRSIGMAR1NISCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250032476-A1 ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF UNIV CALIFORNIA (US) 2025-01-30 US disclosed
EP-4426287-A1 ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF The Regents of the University of California (US) 2024-09-11 EP disclosed
US-20240228514-A1 BORON-CONTAINING ORGANIC COMPOUND AND APPLICATIONS THEREOF SHENZHEN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD. (CN) 2024-07-11 US disclosed
US-20240228514-A1 BORON-CONTAINING ORGANIC COMPOUND AND APPLICATIONS THEREOF SHENZHEN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD. (CN) 2024-07-11 US disclosed
WO-2023098832-A1 PYRIDOPYRIMIDINE DERIVATIVES SERVING AS SMALL GTP ENZYME KRAS MUTATION INHIBITORS 思路迪生物医药(上海)有限公司 2023-06-08 WO disclosed
WO-2023081800-A1 ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-05-11 WO disclosed
WO-2021074357-A1 THIOPHENE DERIVATIVES FOR USE IN TREATING PORTAL INFLAMMATION AND FIBROSIS ENYO PHARMA (FR) 2021-04-22 WO disclosed
CN-107531613-B Benzo-aliphatic ring-substituted alkylamine compound and application thereof 华东理工大学 2021-02-05 CN disclosed
CN-108530241-B Preparation method of benzo ring derivative with benzyl quaternary carbon center 武汉大学 2021-02-02 CN disclosed
CN-110437068-B Preparation method of aromatic methylation 武汉大学 2020-11-03 CN disclosed
EP-3353167-B1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-06-24 EP disclosed
US-20200054651-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-02-20 US disclosed
WO-2019154956-A1 NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES ENYO PHARMA (FR) 2019-08-15 WO disclosed
WO-2018144871-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-08-09 WO disclosed
WO-2017132912-A1 ALKYLAMINE WITH BENZOALICYCLIC SUBSTITUENT AND APPLICATION THEREOF 华东理工大学 2017-08-10 WO disclosed
WO-2017051354-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-03-30 WO disclosed
EP-0357742-B1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES ROUSSEL-UCLAF (FR) 1993-06-09 EP disclosed
EP-0357742-A1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES. ROUSSEL UCLAF (FR) 1990-03-14 EP disclosed
WO-1989008096-A1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES ROUSSEL-UCLAF (FR) 1989-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240228514-A1 BORON-CONTAINING ORGANIC COMPOUND AND APPLICATIONS THEREOF BCL6, SLCO4C1, SLCO2B1 BCL2L1 48/4885BAD 122/4885TSHR 3807/4885
US-20200054651-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A PPP2R1A, PPP3CA, PPP2R2A BCL2L1 1496/4885BAD 2986/4885TSHR 1652/4885
US-20250032476-A1 ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF ADRA2A, ADRB2, ADRA2C BCL2L1 4055/4885BAD 1653/4885TSHR 163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.