Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506159 | 0.70 | CHRNA1 (0.38) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL9735567 | 0.66 | SSTR1 (0.39) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL7213677 | 0.61 | GRM2 (0.38) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL28044887 | 0.61 | IDO1 (0.35) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL8959061 | 0.61 | TRPA1 (0.35) | P2RX7CXCR3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL24135069 | 0.60 | ALDH1A1 (0.44) | GRM2LMNAHPGDALDH1A1HTT | |
| SCHEMBL28527487 | 0.60 | TRPA1 (0.39) | P2RX7SLC6A4SLC6A3POLBLMNA | |
| SCHEMBL20224876 | 0.60 | DRD2 (0.46) | SLC6A2SLC6A4SLC6A3LMNANPSR1 | |
| SCHEMBL14592561 | 0.58 | SSTR1 (0.41) | GRM2POLBLMNAHPGDALDH1A1 | |
| Methyl Alcohol SCHEMBL8781534 | 0.58 | TRPA1 (0.38) | POLBLMNANPSR1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413302-B1 | 1,3-OXAZINES | Dr. Karl Thomae GmbH (DE) | 1993-08-04 | — | — | EP | disclosed |
| US-5114935-A | Antitussive agents | DR. KARL THOMAE GMBH (DE) | 1992-05-19 | — | — | US | disclosed |
| EP-0413302-A1 | 1,3-Oxazines | Dr. Karl Thomae GmbH (DE) | 1991-02-20 | — | — | EP | disclosed |