SCHEMBL950644

SCHEMBL950644

FC(F)(F)Sc1ccn(-c2ncccc2Cl)n1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.34
TRPA1 O75762 3/20 0.33
TRPV1 Q8NER1 3/20 0.32
KCNH2 Q12809 1/20 0.31
TRPM8 Q7Z2W7 1/20 0.31
HSD11B1 P28845 2/20 0.30
KDM4E B2RXH2 2/20 0.30
BRD4 O60885 1/20 0.30
LMNA P02545 1/20 0.30
HSP90AA1 P07900 1/20 0.30
MAPT P10636 1/20 0.30
METAP2 P50579 1/20 0.30
METAP1 P53582 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
ADORA2A P29274 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL949994 0.81 RPS6KA5 (0.36) TRPA1TRPV1KCNH2TRPM8HSD11B1
SCHEMBL12912305 0.78 CNR1 (0.36)
SCHEMBL535692 0.78 KDM4E (0.40) TRPA1TRPV1HSD11B1KDM4EMAPT
SCHEMBL15428454 0.75 TRPA1 (0.34) TRPA1TRPV1KCNH2TRPM8HSD11B1
SCHEMBL639253 0.75 HSD11B1 (0.35) TRPA1TRPV1KCNH2TRPM8HSD11B1
SCHEMBL12912307 0.74 OPRL1 (0.35) KCNN4TRPA1TRPV1KCNH2HSD11B1
SCHEMBL15428453 0.73 TRPA1 (0.33) TRPA1TRPV1KCNH2TRPM8HSD11B1
SCHEMBL435321 0.72 RPS6KA5 (0.35) TRPA1TRPV1KCNH2TRPM8HSD11B1
SCHEMBL950522 0.72 RPS6KA5 (0.34) TRPA1TRPV1KCNH2TRPM8HSD11B1
SCHEMBL29859811 0.72 KDM4E (0.39) TRPA1TRPV1KCNH2TRPM8HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 KCNN4 331/4885TRPA1 437/4885TRPV1 1056/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT KCNN4 574/4885TRPA1 359/4885TRPV1 687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.