Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9543520 | 0.84 | TSHR (0.51) | ALOX5MAPTMEN1KMT2A | |
| SCHEMBL9504638 | 0.81 | ALOX5 (0.64) | HDAC1ALOX5HDAC8MEN1KMT2A | |
| SCHEMBL9504831 | 0.80 | ALOX5 (0.51) | HDAC1ALOX5HDAC8THRATHRB | |
| SCHEMBL9836112 | 0.79 | ALOX5 (0.67) | HDAC1ALOX5HDAC8KDM4AKDM5A | |
| SCHEMBL9504847 | 0.78 | ALOX5 (0.55) | HDAC1ALOX5THRATHRBRCE1 | |
| SCHEMBL9506078 | 0.76 | ALOX5 (0.63) | HDAC1ALOX5HDAC8THRATHRB | |
| SCHEMBL9506247 | 0.75 | KDM4E (0.55) | HDAC1ALOX5HDAC8DPP4MAPT | |
| SCHEMBL28312776 | 0.74 | ALOX5 (0.65) | HDAC1ALOX5HDAC8KDM4AKDM5A | |
| SCHEMBL9508914 | 0.74 | THRA (0.56) | ALOX5THRATHRBMAPTMEN1 | |
| SCHEMBL9504721 | 0.74 | THRA (0.63) | ALOX5THRATHRBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| CN-85104470-A | The method for preparing arythydroxamtes | — | 1986-10-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |