Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25506006 | 0.91 | HRH3 (0.45) | CHKAHRH3ADRB2NCF1PLD1 | |
| SCHEMBL20320110 | 0.86 | CHKA (0.35) | CHKAHRH3ADRB2NCF1PLD1 | |
| SCHEMBL25506008 | 0.81 | ADRB2 (0.42) | CHKAADRB2NCF1PLD1 | |
| Hydrochloric Acid SCHEMBL25183378 | 0.79 | ADRB2 (0.41) | CHKAADRB2NCF1PLD1 | |
| SCHEMBL6864215 | 0.76 | FFAR1 (0.41) | GAAMAPTL3MBTL1USP2 | |
| SCHEMBL49369 | 0.74 | LMNA (0.39) | CHKAADRB2NCF1PLD1BCHE | |
| SCHEMBL6757668 | 0.73 | AR (0.33) | JAK3 | |
| SCHEMBL5557815 | 0.73 | ALDH1A1 (0.42) | GAALMNAMAPTNPSR1TDP1 | |
| SCHEMBL16992336 | 0.72 | CCNA2 (0.40) | HRH3BCHENPSR1USP2 | |
| SCHEMBL18444563 | 0.72 | CCNA2 (0.40) | HRH3BCHENPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287340-B1 | NOVEL ACYLATION PROCESS FOR THE SYNTHESIS OF HMG-COA REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1993-09-29 | — | — | EP | claimed |
| US-4845237-A | ANTIHYPERCHOLESTEROLEMIC COMPOUNDS | MERCK & CO., INC. (US) | 1989-07-04 | — | — | US | claimed |