Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507584 | 1.00 | CYP1B1 (0.54) | CYP1B1RORCALDH1A1CYP3A4HPGD | |
| SCHEMBL11404198 | 0.85 | CYP1B1 (0.65) | CYP1B1RORCALDH1A1CYP3A4HPGD | |
| SCHEMBL1643202 | 0.82 | ALDH1A1 (0.48) | CYP1B1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL1643205 | 0.82 | ALDH1A1 (0.48) | CYP1B1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL28610776 | 0.82 | ALDH1A1 (0.48) | CYP1B1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5484284 | 0.78 | CA2 (0.50) | RORCALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5484286 | 0.78 | CA2 (0.50) | RORCALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL10766481 | 0.77 | CYP1B1 (0.45) | CYP1B1CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27984216 | 0.75 | NFE2L2 (0.54) | CYP1B1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL30633421 | 0.74 | SMN1; SMN2 (0.41) | CYP1B1ALDH1A1HPGDMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172234-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110172234-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-07-14 | — | — | US | disclosed |
| US-7915245-B2 | Using small molecules as binding ligands, for the recruitment of Fas-associated death domain protein, activation of death-inducing signaling complex, caspase-8, and apoptosis in malignant cells; anticarcinogens, antitumor agents; enhanced cellular differentiation, minimizing cytolysis to healthy cells | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915245-B2 | Using small molecules as binding ligands, for the recruitment of Fas-associated death domain protein, activation of death-inducing signaling complex, caspase-8, and apoptosis in malignant cells; anticarcinogens, antitumor agents; enhanced cellular differentiation, minimizing cytolysis to healthy cells | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-03-29 | — | — | US | disclosed |
| US-20080214547-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2008-09-04 | — | — | US | disclosed |
| US-20080214547-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2008-09-04 | — | — | US | disclosed |
| EP-0205083-B1 | IMAGE FORMING METHOD AND TRANSFER RECORDING MEDIUM THEREFOR | CANON KABUSHIKI KAISHA (JP) | 1993-09-01 | — | — | EP | disclosed |
| EP-0261394-B1 | IMAGE RECORDING APPARATUS | CANON KABUSHIKI KAISHA (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-5015552-A | Multilayer optical image recording process involving crosslinking, treatment with heat or light, transferring | CANON KABUSHIKI KAISHA (JP) | 1991-05-14 | — | — | US | disclosed |
| US-5005028-A | Image forming method and transfer recording medium therefor | CANON KABUSHIKI KAISHA (JP) | 1991-04-02 | — | — | US | disclosed |
| US-4990931-A | Image forming method and apparatus therefor | CANON KABUSHIKI KAISHA (JP) | 1991-02-05 | — | — | US | disclosed |
| US-4978968-A | Image recording apparatus | CANON KABUSHIKI KAISHA (JP) | 1990-12-18 | — | — | US | disclosed |
| EP-0205083-A2 | Image forming method and transfer recording medium therefor | CANON KABUSHIKI KAISHA (JP) | 1986-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214547-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | BID, BAD, MCL1 | CYP1B1 4007/4885RORC 2385/4885ALDH1A1 3768/4885 |
| US-20110172234-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | BID, BAD, MCL1 | CYP1B1 4007/4885RORC 2385/4885ALDH1A1 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.