Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31187414 | 1.00 | NPC1 (0.41) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL9769197 | 0.84 | CES2 (0.39) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL16554270 | 0.83 | CA12 (0.40) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL30854918 | 0.79 | NPC1 (0.63) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL1790008 | 0.79 | NPC1 (0.63) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL3901324 | 0.77 | LMNA (0.38) | KMT2AMEN1MAOBALDH1A1TSHR | |
| SCHEMBL20816106 | 0.77 | NPC1 (0.43) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL7912420 | 0.76 | CES2 (0.46) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL9489048 | 0.76 | PAX8 (0.57) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL7754386 | 0.76 | MAPT (0.38) | RAB9ACES2CES1PAX8MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391191-B1 | (METH)ACRYLIC POLYMERS GRAFTED WITH POLYCARBONATE CHAINS, THEIR MANUFACTURE AND USE | BAYER AG (DE) | 1993-09-01 | — | — | EP | disclosed |
| EP-0292785-B1 | VINYL COPOLYMERES CONTAINING GRAFTED POLYCARBONATE CHAINS, THEIR MANUFACTURE AND USE | BAYER AG (DE) | 1991-06-05 | — | — | EP | disclosed |
| EP-0391191-A2 | (Meth)acrylic polymers grafted with polycarbonate chains, their manufacture and use | BAYER AG (DE) | 1990-10-10 | — | — | EP | disclosed |
| US-4946921-A | POLYSILICATE CONTAINING HYDROXYPHENYL GROUP | TORAY SILICONE COMPANY LIMITED (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0342648-A2 | Alkali-soluble organopolysiloxane | TORAY SILICONE COMPANY, LIMITED (JP) | 1989-11-23 | — | — | EP | disclosed |