Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9509061 | 0.84 | SIGMAR1 (0.46) | KIF11SIGMAR1KDM1APDK2MEN1 | |
| SCHEMBL9509760 | 0.84 | KDM1A (0.42) | SIGMAR1KDM1AMEN1KMT2ATP53 | |
| SCHEMBL9508313 | 0.83 | KDM1A (0.46) | SLC6A4SLC6A3SIGMAR1KDM1APDK2 | |
| SCHEMBL9509084 | 0.82 | SIGMAR1 (0.48) | SLC6A4SLC6A3SIGMAR1KDM1APDK2 | |
| SCHEMBL9512045 | 0.80 | SIGMAR1 (0.43) | SIGMAR1KDM1APDK2MEN1KMT2A | |
| SCHEMBL9509759 | 0.80 | KDM1A (0.40) | SLC6A4SIGMAR1KDM1APDK2MEN1 | |
| SCHEMBL9508294 | 0.72 | SIGMAR1 (0.48) | KIF11SIGMAR1KDM1APDK2MEN1 | |
| SCHEMBL9509089 | 0.71 | PDK2 (0.40) | SIGMAR1KDM1APDK2AKR1B1 | |
| SCHEMBL11812318 | 0.71 | CCR2 (0.44) | KIF11SLC6A4SLC6A3SLC6A2SIGMAR1 | |
| SCHEMBL9509137 | 0.70 | MEN1 (0.42) | SIGMAR1KDM1APDK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414686-B1 | DERIVATIVES OF TRIFLUOROMETHYL-1-TETRALINES, PREPARATION AND APPLICATION THEREOF FOR THE SYNTHESIS OF COMPOUNDS HAVING THERAPEUTIC PROPERTIES | LABORATOIRES LUCIEN (FR) | 1993-09-22 | — | — | EP | claimed |