Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965483 | 0.74 | AOC3 (0.52) | HDAC3HDAC1HDAC2NCOR2RAB9A | |
| SCHEMBL12083406 | 0.72 | ALDH1A1 (0.59) | TYMSHTR6CXCR4L3MBTL1 | |
| SCHEMBL4664189 | 0.71 | TYMS (0.46) | TYMSHTR6L3MBTL1 | |
| SCHEMBL4664193 | 0.71 | TYMS (0.46) | TYMSHTR6CXCR4L3MBTL1CRHBP | |
| SCHEMBL9701972 | 0.71 | TYMS (0.53) | TYMSHTR6SCN9AFFAR2 | |
| SCHEMBL9504568 | 0.70 | TYMS (0.69) | TYMSHTR6FFAR2CRHBPCRHR2 | |
| SCHEMBL9587756 | 0.68 | TYMS (0.43) | TYMSHTR6HDAC3HDAC1HDAC2 | |
| SCHEMBL9508662 | 0.68 | TYMS (0.59) | TYMSRAB9ACRHBPCRHR2 | |
| SCHEMBL1065778 | 0.67 | DHFR (0.59) | TYMS | |
| SCHEMBL158288 | 0.67 | HTR6 (0.71) | HTR6LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550566-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS (US) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005153-A1 | ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS, INC. (US) | 1992-04-02 | — | — | WO | disclosed |