Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 4/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194475 | 0.93 | HMGCR (0.45) | HMGCRMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9199852 | 0.88 | HMGCR (0.42) | HMGCRMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9197287 | 0.85 | HMGCR (0.38) | HMGCRMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8780157 | 0.82 | PTGS2 (0.37) | HMGCRCA1CA2GCGRRPS6KA3 | |
| SCHEMBL9512239 | 0.80 | CA1 (0.53) | HMGCRCYP1A2CA1CA2GCGR | |
| SCHEMBL8780176 | 0.78 | GABRA1 (0.50) | HMGCRCA1CA2GCGRRPS6KA3 | |
| SCHEMBL9199239 | 0.77 | CA1 (0.41) | HMGCRCYP1A2CA1CA2GCGR | |
| SCHEMBL9514348 | 0.75 | CA1 (0.47) | HMGCRMEN1KMT2ACA1CA2 | |
| SCHEMBL9516053 | 0.75 | CA1 (0.39) | CA1CA2 | |
| SCHEMBL9701896 | 0.73 | CA1 (0.61) | MEN1CYP1A2CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668126-A | ORAL ADMINISTRATION OF HMG-COA REDUCTASE INHIBITOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-16 | — | — | US | disclosed |
| US-5646272-A | WITH IMPROVED ABSORPTION INTO THE BLOODSTREAM | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | disclosed |
| EP-0417725-B1 | Bile-acid derivatives, a process for their production and their use as medicines | HOECHST AG (DE) | 1997-04-23 | — | — | EP | disclosed |
| US-5462933-A | Oral administering | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0418648-B1 | 4-Hydroxytetrahydropyran-2-ones as well as the corresponding dehydroxy carbon acid derivatives, salts and esters, process for their preparation, pharmaceutical preparations as well as precursors | HOECHST AG (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5294724-A | Anticholesterol agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | disclosed |
| EP-0418648-A1 | 4-Hydroxytetrahydropyran-2-ones as well as the corresponding dehydroxy carbon acid derivatives, salts and esters, process for their preparation, pharmaceutical preparations as well as precursors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-27 | — | — | EP | disclosed |
| EP-0417725-A2 | Bile-acid derivatives, a process for their production and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |