Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | HMGCR | P04035 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512239 | 0.83 | CA1 (0.53) | CA1CA2GCGRHSP90AA1HSP90AB1 | |
| SCHEMBL8780176 | 0.82 | GABRA1 (0.50) | CA1CA2GCGRHSP90AA1HSP90AB1 | |
| SCHEMBL9516053 | 0.78 | CA1 (0.39) | CA1CA2 | |
| SCHEMBL9514348 | 0.78 | CA1 (0.47) | CA1CA2HSP90AA1GABRA1GABRB1 | |
| SCHEMBL8780227 | 0.77 | HMGCR (0.50) | CA1CA2GCGRRPS6KA3GSK3B | |
| SCHEMBL9197287 | 0.77 | HMGCR (0.38) | CA1CA2GCGRHSP90AA1HSP90AB1 | |
| SCHEMBL10026552 | 0.75 | CA1 (0.68) | CA1CA2GCGRRPS6KA3GABRA1 | |
| SCHEMBL8780124 | 0.75 | GABRA1 (0.55) | CA1CA2GCGRHSP90AA1HSP90AB1 | |
| SCHEMBL647950 | 0.74 | CA1 (0.64) | CA1CA2HSP90AA1HSP90AB1GABRA1 | |
| SCHEMBL8780157 | 0.74 | PTGS2 (0.37) | CA1CA2GCGRHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418648-B1 | 4-Hydroxytetrahydropyran-2-ones as well as the corresponding dehydroxy carbon acid derivatives, salts and esters, process for their preparation, pharmaceutical preparations as well as precursors | HOECHST AG (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5294724-A | Anticholesterol agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | disclosed |
| EP-0418648-A1 | 4-Hydroxytetrahydropyran-2-ones as well as the corresponding dehydroxy carbon acid derivatives, salts and esters, process for their preparation, pharmaceutical preparations as well as precursors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-27 | — | — | EP | disclosed |