Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SORD | Q00796 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276896 | 0.80 | MAP4K4 (0.51) | TRPV1SORDLSS | |
| SCHEMBL6977620 | 0.77 | HRH3 (0.48) | TRPV1KDM4ESORDLSS | |
| SCHEMBL9513674 | 0.75 | KDM4E (0.59) | KDM4E | |
| SCHEMBL14029975 | 0.72 | HRH4 (0.67) | KDM4ESORD | |
| SCHEMBL24799135 | 0.71 | SORD (0.48) | KMT2ASORDLSS | |
| SCHEMBL3167113 | 0.71 | CXCR4 (0.49) | KMT2AKDM4ESORD | |
| SCHEMBL6982738 | 0.71 | SORD (0.41) | SORDPIK3CDPIK3CALSS | |
| SCHEMBL6975264 | 0.71 | GPR119 (0.54) | KMT2A | |
| SCHEMBL9514848 | 0.71 | ALDH1A1 (0.64) | KMT2AKDM4E | |
| SCHEMBL15698589 | 0.71 | SORD (0.52) | KMT2ASORD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384370-B1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AG (DE) | 1993-11-03 | — | — | EP | disclosed |
| US-5138058-A | Diabetic screening | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0384370-A1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-29 | — | — | EP | disclosed |