Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | CKS1B | P61024 | 1/20 | 0.56 |
| ▸ | SKP1 | P63208 | 1/20 | 0.56 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 5/20 | 0.56 |
| ▸ | GBA1 | P04062 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514848 | 0.87 | ALDH1A1 (0.64) | KDM4EALDH1A1MAPK1SMN1; SMN2PKM | |
| SCHEMBL14276896 | 0.81 | MAP4K4 (0.51) | CKS1BSKP1SKP2GBA1ALDH1A1 | |
| SCHEMBL6980429 | 0.81 | SLC6A7 (0.56) | KDM4ESLC6A7GBA1ALDH1A1MAPK1 | |
| SCHEMBL13115595 | 0.77 | KDM4E (0.67) | KDM4ECKS1BSKP1SKP2SLC6A7 | |
| SCHEMBL7655661 | 0.76 | LSS (0.48) | KDM4EHPGD | |
| SCHEMBL9730560 | 0.76 | GBA1 (0.62) | KDM4ECKS1BSKP1SKP2SLC6A7 | |
| SCHEMBL6977620 | 0.76 | HRH3 (0.48) | KDM4EGBA1ALDH1A1HPGD | |
| SCHEMBL11080932 | 0.75 | SLC6A7 (0.85) | KDM4ECKS1BSKP1SKP2SLC6A7 | |
| SCHEMBL9513664 | 0.75 | KMT2A (0.50) | KDM4E | |
| SCHEMBL22383506 | 0.74 | HSD17B10 (0.53) | KDM4ESLC6A7GBA1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384370-B1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AG (DE) | 1993-11-03 | — | — | EP | disclosed |
| US-5138058-A | Diabetic screening | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0384370-A1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-29 | — | — | EP | disclosed |