Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 18/20 | 0.58 |
| ▸ | CA2 | P00918 | 18/20 | 0.58 |
| ▸ | CA9 | Q16790 | 17/20 | 0.58 |
| ▸ | CA12 | O43570 | 12/20 | 0.58 |
| ▸ | CA7 | P43166 | 11/20 | 0.58 |
| ▸ | CA4 | P22748 | 9/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 9/20 | 0.58 |
| ▸ | CA5A | P35218 | 7/20 | 0.58 |
| ▸ | CA13 | Q8N1Q1 | 7/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642630 | 0.81 | HRH3 (0.55) | HRH3KCNJ1KCNH2 | |
| SCHEMBL27928479 | 0.81 | HRH3 (0.60) | CA1CA2CA9CA12CA7 | |
| SCHEMBL28327802 | 0.80 | THRB (0.59) | HRH3KCNJ1KCNH2 | |
| SCHEMBL8153546 | 0.77 | THRB (0.63) | HRH3KCNH2 | |
| SCHEMBL9514721 | 0.77 | CA2 (0.61) | CA1CA2CA9CA12CA7 | |
| SCHEMBL4777747 | 0.76 | CA2 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL9515031 | 0.73 | HTR1A (0.53) | CA1CA2CA9CA12CA7 | |
| SCHEMBL4572801 | 0.72 | SIGMAR1 (0.60) | HRH3KCNH2 | |
| SCHEMBL6619070 | 0.71 | NOS1 (0.79) | HRH3KCNH2 | |
| SCHEMBL28327814 | 0.71 | LIPG (0.50) | CA1CA2CA9HRH3KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |
| CN-87100652-A | ANTI-DYSRHYTHMIA AGENTS | — | 1987-08-19 | — | — | CN | disclosed |