Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.47 |
| ▸ | DRD4 | P21917 | 8/20 | 0.47 |
| ▸ | DRD1 | P21728 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | DRD5 | P21918 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9517655 | 0.90 | HRH2 (0.53) | DRD2DRD4DRD1DRD3DRD5 | |
| Fumaric Acid SCHEMBL9517664 | 0.90 | HRH2 (0.53) | DRD2DRD4DRD1DRD3DRD5 | |
| Hydrochloric Acid SCHEMBL9517753 | 0.88 | DRD2 (0.44) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL11098584 | 0.86 | DRD2 (0.51) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL9518975 | 0.86 | DRD1 (0.52) | DRD2DRD4DRD1DRD3DRD5 | |
| SCHEMBL9515621 | 0.82 | CYP2D6 (0.51) | DRD2DRD4DRD3CYP2D6HRH1 | |
| SCHEMBL9515694 | 0.79 | ALDH1A1 (0.46) | CYP3A4CYP2D6MAPTCYP2C19TP53 | |
| SCHEMBL9615962 | 0.78 | SETD7 (0.59) | DRD2DRD4DRD1DRD3DRD5 | |
| Fumaric Acid SCHEMBL9516875 | 0.75 | CYP2D6 (0.44) | DRD2DRD4CYP2D6MAPTHRH4 | |
| SCHEMBL11099611 | 0.73 | SETD7 (0.47) | DRD2DRD4DRD1DRD3DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0423870-B1 | DIBENZODIOXAZECINE AND DIBENZODIOXAAZACYCLOUNDECINE DERIVATIVES | Akzo Nobel N.V. (NL) | 1993-07-14 | — | — | EP | disclosed |
| US-5106839-A | DIBENZODIOXAZECINE AND DIBENZODIOXAAZACYCLOUNDECINE DERIVATIVES | AKZO N.V. (NL) | 1992-04-21 | — | — | US | disclosed |
| EP-0423870-A1 | Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives | Akzo Nobel N.V. (NL) | 1991-04-24 | — | — | EP | disclosed |