Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.43 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.43 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.43 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.42 |
| ▸ | DRD1 known ✓ | P21728 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | DRD5 | P21918 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9517664 | 1.00 | HRH2 (0.53) | HRH2LMNASMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL9515147 | 0.90 | DRD2 (0.47) | HRH2LMNASMN1; SMN2TP53HRH4 | |
| Fumaric Acid SCHEMBL9516875 | 0.86 | CYP2D6 (0.44) | HRH2LMNAHRH4DRD4DRD2 | |
| Maleic Acid SCHEMBL29935486 | 0.82 | HTT (0.50) | HRH2LMNASMN1; SMN2L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL9517753 | 0.79 | DRD2 (0.44) | HRH2LMNASMN1; SMN2TP53HRH4 | |
| SCHEMBL11098584 | 0.77 | DRD2 (0.51) | HRH2LMNASMN1; SMN2TP53HRH4 | |
| SCHEMBL9518975 | 0.77 | DRD1 (0.52) | LMNASMN1; SMN2DRD4ADRA2ADRD2 | |
| SCHEMBL9515694 | 0.77 | ALDH1A1 (0.46) | HRH2LMNASMN1; SMN2TP53MAPK1 | |
| SCHEMBL9515621 | 0.76 | CYP2D6 (0.51) | HRH1DRD4ADRA2ADRD2DRD3 | |
| Clopipazan SCHEMBL11573662 | 0.75 | SETD7 (0.61) | HRH2LMNASMN1; SMN2L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0423870-B1 | DIBENZODIOXAZECINE AND DIBENZODIOXAAZACYCLOUNDECINE DERIVATIVES | Akzo Nobel N.V. (NL) | 1993-07-14 | — | — | EP | disclosed |
| EP-0423870-A1 | Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives | Akzo Nobel N.V. (NL) | 1991-04-24 | — | — | EP | disclosed |