Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 5/20 | 0.52 |
| ▸ | DRD5 | P21918 | 5/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | DRD4 | P21917 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9615962 | 0.88 | SETD7 (0.59) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL9515147 | 0.86 | DRD2 (0.47) | DRD1DRD5DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL9517633 | 0.85 | MAOA (0.49) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL11141355 | 0.81 | DRD1 (0.54) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL11131856 | 0.81 | MAOA (0.68) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL11096596 | 0.80 | DRD1 (0.72) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL1203639 | 0.80 | ITGB2 (0.54) | MAOAMAOBITGB2ICAM1ITGAL | |
| Hydrochloric Acid SCHEMBL11095470 | 0.79 | MAOA (0.69) | DRD1DRD5DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL11254459 | 0.79 | MAOA (0.53) | DRD1DRD5DRD2DRD4DRD3 | |
| Maleic Acid SCHEMBL9517655 | 0.77 | HRH2 (0.53) | DRD1DRD5DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0423870-B1 | DIBENZODIOXAZECINE AND DIBENZODIOXAAZACYCLOUNDECINE DERIVATIVES | Akzo Nobel N.V. (NL) | 1993-07-14 | — | — | EP | disclosed |
| US-5106839-A | DIBENZODIOXAZECINE AND DIBENZODIOXAAZACYCLOUNDECINE DERIVATIVES | AKZO N.V. (NL) | 1992-04-21 | — | — | US | disclosed |
| EP-0423870-A1 | Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives | Akzo Nobel N.V. (NL) | 1991-04-24 | — | — | EP | disclosed |