Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11345973 | 0.82 | CES2 (0.40) | CA2CAMK2ACYP1A2CYP2D6MAPK1 | |
| SCHEMBL9630131 | 0.82 | TGM2 (0.47) | NPC1RAB9ACYP1A2CYP2D6MAPK1 | |
| SCHEMBL2456680 | 0.82 | CES1 (0.52) | FNTAFNTBCTBP2MAPK1LMNA | |
| SCHEMBL6557829 | 0.82 | CA2 (0.54) | CA2CAMK2AFNTAFNTBCTBP2 | |
| SCHEMBL7150590 | 0.80 | CA2 (0.68) | CA2CAMK2AFNTAFNTBCTBP2 | |
| SCHEMBL7174072 | 0.79 | KDM4E (0.56) | CA2HSD17B10LMNAMEN1KMT2A | |
| SCHEMBL14075477 | 0.79 | LMNA (0.54) | CA2CAMK2AFNTAFNTBNPC1 | |
| SCHEMBL9339427 | 0.78 | SMN1; SMN2 (0.43) | CA2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8656429 | 0.78 | SMN1; SMN2 (0.55) | CTBP2NPC1SMN1; SMN2LMNA | |
| SCHEMBL8966426 | 0.77 | CA2 (0.48) | CA2CAMK2AFNTAFNTBCTBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236624-B1 | SUBSTITUTED PHENYL ETHANOL AMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-08-11 | — | — | EP | disclosed |
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |
| EP-0095827-B1 | N-SUBSTITUTED DERIVATIVES OF ETHANOL AMINE | BEECHAM GROUP PLC (GB) | 1985-07-24 | — | — | EP | disclosed |
| EP-0095827-A1 | N-substituted derivatives of ethanol amine | BEECHAM GROUP PLC (GB) | 1983-12-07 | — | — | EP | disclosed |
| EP-0023385-B1 | ETHANAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| EP-0052963-A1 | Secondary amines | BEECHAM GROUP PLC (GB) | 1982-06-02 | — | — | EP | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |