Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.37 |
| ▸ | MICA | Q29983 | 1/20 | 0.37 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519439 | 0.95 | PNMT (0.42) | PNMTHDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL9517180 | 0.90 | PNMT (0.44) | PNMTHDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL9515974 | 0.89 | HIF1A (0.39) | HDAC1HDAC6HDAC5HDAC8HDAC3 | |
| SCHEMBL9515550 | 0.88 | MEN1 (0.36) | HDAC1HDAC6HDAC5HDAC8HDAC3 | |
| SCHEMBL9516279 | 0.84 | HIF1A (0.39) | HDAC1HDAC6HDAC5HDAC8HDAC3 | |
| SCHEMBL9516716 | 0.83 | EPHX2 (0.36) | HDAC1HDAC6HDAC5HDAC8HDAC3 | |
| SCHEMBL9519314 | 0.81 | EGFR (0.37) | HDAC6 | |
| SCHEMBL9518016 | 0.81 | MEN1 (0.38) | HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9515897 | 0.79 | EGFR (0.42) | HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9517174 | 0.79 | HDAC1 (0.39) | HDAC1HDAC6HDAC5HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |