Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.38 |
| ▸ | MICA | Q29983 | 1/20 | 0.38 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519391 | 0.88 | HDAC6 (0.38) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9519634 | 0.87 | HDAC1 (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9517025 | 0.87 | CASP3 (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9519433 | 0.87 | NAMPT (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9517165 | 0.86 | VNN1 (0.40) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9515429 | 0.85 | HDAC1 (0.38) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9517180 | 0.82 | PNMT (0.44) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9518019 | 0.81 | MEN1 (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9519439 | 0.80 | PNMT (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9515431 | 0.79 | PNMT (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |