Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 9/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | CASP4 | P49662 | 1/20 | 0.35 |
| ▸ | CASP5 | P51878 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516974 | 0.91 | EGFR (0.44) | P4HTMEGFRMEN1NPC1RAB9A | |
| SCHEMBL9516990 | 0.88 | P4HTM (0.37) | P4HTMEGFRCASP3HDAC6SCN9A | |
| SCHEMBL9517314 | 0.87 | P4HTM (0.36) | P4HTMEGFRCASP3HDAC6SCN9A | |
| SCHEMBL9516948 | 0.85 | P4HTM (0.37) | P4HTMEGFRMEN1NPC1RAB9A | |
| SCHEMBL9518019 | 0.84 | MEN1 (0.39) | P4HTMMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9519628 | 0.84 | BCL2L1 (0.42) | P4HTMNPC1RAB9AL3MBTL1CASP3 | |
| SCHEMBL9519311 | 0.83 | P4HTM (0.36) | P4HTMEGFRMEN1NPC1RAB9A | |
| SCHEMBL9517025 | 0.83 | CASP3 (0.39) | P4HTMMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9515768 | 0.82 | HIF1A (0.40) | P4HTMMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9517174 | 0.81 | HDAC1 (0.39) | CASP3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |