Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517994 | 0.88 | P4HTM (0.49) | P4HTML3MBTL1MAPTALDH1A1GAA | |
| SCHEMBL9517110 | 0.87 | P4HTM (0.61) | P4HTMPTGS2PTGS1FLT1FLT4 | |
| SCHEMBL9517241 | 0.85 | P4HTM (0.61) | P4HTMPTGS2PTGS1BCL2L1MCL1 | |
| SCHEMBL9519208 | 0.84 | P4HTM (0.39) | P4HTMFLT1FLT4KDRMAPT | |
| SCHEMBL9518074 | 0.84 | P4HTM (0.39) | P4HTMPTGS2FLT1FLT4KDR | |
| SCHEMBL9516058 | 0.83 | KMT2A (0.50) | L3MBTL1MAPTALDH1A1GAATSHR | |
| SCHEMBL9515753 | 0.83 | GABRA5 (0.50) | P4HTML3MBTL1MAPTALDH1A1GAA | |
| SCHEMBL9516016 | 0.83 | P4HTM (0.58) | P4HTMPTGS2PTGS1BCL2L1MCL1 | |
| SCHEMBL9566757 | 0.83 | RAB9A (0.52) | P4HTML3MBTL1ALDH1A1GAAKMT2A | |
| SCHEMBL9517201 | 0.82 | TSHR (0.52) | MAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |