Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519649 | 0.90 | GRM5 (0.38) | GRM5HDAC6SLC6A9SLC6A5GABRA5 | |
| SCHEMBL9517911 | 0.89 | CXCR1 (0.37) | HDAC6GABRA5P4HTM | |
| SCHEMBL9519398 | 0.88 | SCD (0.41) | HDAC6SCN9A | |
| SCHEMBL9517030 | 0.86 | SLC6A9 (0.39) | GRM5LMNAHDAC6SLC6A9SLC6A5 | |
| SCHEMBL9516327 | 0.85 | APLNR (0.39) | LMNAHDAC6SCN9AGABRA5P4HTM | |
| SCHEMBL9516994 | 0.84 | SCN9A (0.38) | HDAC6SCN9AP4HTMSCN5A | |
| SCHEMBL9517233 | 0.84 | POLB (0.38) | GRM5LMNAHDAC6GABRA5P4HTM | |
| SCHEMBL9516262 | 0.83 | GRM5 (0.40) | GRM5LMNAHDAC6SLC6A9SLC6A5 | |
| SCHEMBL9517939 | 0.83 | EGFR (0.40) | SCN9AP4HTMSCN5A | |
| SCHEMBL9516012 | 0.82 | HSD11B1 (0.39) | HDAC6SCN9AP4HTMKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |