Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519649 | 0.88 | GRM5 (0.38) | GRM5P4HTMHDAC6GABRA5 | |
| SCHEMBL9517229 | 0.85 | POLB (0.38) | POLBSMN1; SMN2TDP1L3MBTL1KDM4E | |
| SCHEMBL9516266 | 0.84 | GRM5 (0.38) | GRM5LMNAP4HTMHDAC6GABRA5 | |
| SCHEMBL9517030 | 0.81 | SLC6A9 (0.39) | POLBL3MBTL1RAB9AGRM5LMNA | |
| SCHEMBL9517093 | 0.79 | P4HTM (0.39) | GAAADRB2ADRB1ADRB3MAPT | |
| SCHEMBL9517994 | 0.78 | P4HTM (0.49) | POLBSMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL9515753 | 0.77 | GABRA5 (0.50) | POLBSMN1; SMN2TDP1L3MBTL1KDM4E | |
| SCHEMBL9519641 | 0.77 | SCD (0.41) | SCDHDAC6 | |
| SCHEMBL9515611 | 0.77 | EPHX2 (0.39) | P4HTMHDAC6 | |
| SCHEMBL9515933 | 0.76 | P4HTM (0.55) | L3MBTL1KDM4EGAATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |