SCHEMBL9516828

SCHEMBL9516828

NS(=O)(=O)c1cc(Cl)c(NC(=O)COCCO)c(S(N)(=O)=O)c1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.47
POLB P06746 2/20 0.47
CA1 P00915 16/20 0.43
CA2 P00918 16/20 0.43
CA9 Q16790 2/20 0.42
CA12 O43570 1/20 0.42
LMNA P02545 1/20 0.42
CYP2C9 P11712 1/20 0.42
CA4 P22748 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA7 P43166 1/20 0.42
CA13 Q8N1Q1 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CA5B Q9Y2D0 1/20 0.42
APEX1 P27695 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
PLK1 P53350 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9699754 0.83 CA1 (0.50) L3MBTL1POLBCA1CA2CA9
SCHEMBL9515496 0.77 L3MBTL1 (0.39) L3MBTL1POLBCA1CA2CA9
SCHEMBL9701011 0.71 CA2 (0.51) L3MBTL1POLBCA1CA2CA9
SCHEMBL9516820 0.70 CA1 (0.46) L3MBTL1POLBCA1CA2CA9
SCHEMBL9516814 0.65 CA2 (0.51) L3MBTL1POLBCA1CA2CA9
SCHEMBL28429068 0.63 ALDH1A1 (0.54) L3MBTL1POLBLMNA
SCHEMBL6906930 0.62 CA1 (0.69) L3MBTL1POLBCA1CA2CA9
SCHEMBL9518035 0.62 APEX1 (1.00) L3MBTL1POLBCA1CA2CA9
Dichlorphenamide SCHEMBL112376 0.62 CA1 (1.00) L3MBTL1POLBCA1CA2CA9
Dichlorphenamide SCHEMBL29355725 0.62 CA1 (1.00) L3MBTL1POLBCA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0539527-A1 ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1993-05-05 EP disclosed
US-5157044-A Treating glaucoma UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-10-20 US disclosed
US-5095026-A PRODRUGS OF CARBONIC ANHYDRASE INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-03-10 US disclosed
WO-1992000287-A2 ANALOGS OF CARBONIC ANHYDRASE INHIBITORS AND THEIR USE AS TOPICAL IOP INHIBITORS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1992-01-09 WO disclosed