Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518150 | 0.86 | MEN1 (0.47) | MEN1KMT2AMAPTALDH1A1AR | |
| SCHEMBL9516058 | 0.85 | KMT2A (0.50) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL9515571 | 0.84 | HDAC1 (0.46) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL9517110 | 0.82 | P4HTM (0.61) | MEN1KMT2ALMNA | |
| SCHEMBL9517193 | 0.79 | AR (0.59) | MEN1KMT2AMAPTALDH1A1AR | |
| SCHEMBL9777072 | 0.78 | AR (0.62) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL9654495 | 0.75 | HDAC1 (0.52) | MEN1KMT2AALDH1A1TDP1PKM | |
| SCHEMBL9657802 | 0.74 | HDAC1 (0.53) | MEN1KMT2AALDH1A1TDP1PKM | |
| SCHEMBL7782225 | 0.74 | NHERF1 (0.76) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL9656277 | 0.74 | KMT2A (0.48) | MEN1KMT2AMAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |