Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654381 | 0.88 | PKM (0.46) | KMT2AMEN1HDAC1HDAC8PKM | |
| SCHEMBL9654495 | 0.88 | HDAC1 (0.52) | KMT2AMEN1HDAC1HDAC8PKM | |
| SCHEMBL9657802 | 0.84 | HDAC1 (0.53) | KMT2AMEN1HDAC1HDAC8PKM | |
| SCHEMBL9656939 | 0.82 | HDAC1 (0.52) | HDAC1HDAC8PKMTSHRMAPK1 | |
| SCHEMBL9655939 | 0.82 | KDM4E (0.47) | KMT2AMEN1HDAC1HDAC8HPGD | |
| SCHEMBL9656883 | 0.80 | ALDH1A1 (0.60) | KMT2AMEN1HPGDMAPTALDH1A1 | |
| SCHEMBL9656899 | 0.78 | TBXAS1 (0.51) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL9654550 | 0.78 | IDO1 (0.49) | KMT2AMEN1HDAC1HDAC8NPSR1 | |
| SCHEMBL9518150 | 0.77 | MEN1 (0.47) | KMT2AMEN1HDAC1HDAC8PKM | |
| SCHEMBL9656208 | 0.76 | PGR (0.52) | HDAC1HDAC8PKMTDP1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287270-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-4902698-A | Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub.2 | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-20 | — | — | US | disclosed |
| EP-0287270-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |