Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516953 | 0.89 | P4HTM (0.39) | P4HTMGABRA5SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL9516209 | 0.83 | P4HTM (0.38) | P4HTMGABRA5ALDH1A1GSK3BPKM | |
| SCHEMBL9517223 | 0.83 | P4HTM (0.41) | P4HTMGABRA5NPC1RAB9AALDH1A1 | |
| SCHEMBL9517975 | 0.82 | P4HTM (0.53) | P4HTMSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9517110 | 0.79 | P4HTM (0.61) | P4HTMLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL9516040 | 0.78 | GABRA5 (0.41) | P4HTMGABRA5SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL9517942 | 0.78 | P4HTM (0.47) | P4HTMGABRA5ALDH1A1LMNAHTT | |
| SCHEMBL9517031 | 0.77 | P4HTM (0.39) | P4HTMGABRA5SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9517093 | 0.76 | P4HTM (0.39) | P4HTMALDH1A1ADRB2ADRB1ADRB3 | |
| SCHEMBL9519173 | 0.75 | P4HTM (0.58) | P4HTMHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |