Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 4/20 | 0.59 |
| ▸ | ITGB3 known ✓ | P05106 | 2/20 | 0.50 |
| ▸ | ITGA2B known ✓ | P08514 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.57 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | MME | P08473 | 4/20 | 0.53 |
| ▸ | CPA1 | P15085 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.51 |
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7103036 | 1.00 | ACE (0.59) | ACEFOLH1NAALAD2CA1CA2 | |
| Water SCHEMBL27998556 | 1.00 | ACE (0.59) | ACEFOLH1NAALAD2CA1CA2 | |
| Water SCHEMBL22150379 | 1.00 | ACE (0.59) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL3459805 | 0.98 | ACE (0.60) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL479125 | 0.98 | ACE (0.60) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL7110125 | 0.98 | ACE (0.60) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL479126 | 0.98 | ACE (0.60) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL7110134 | 0.98 | ACE (0.60) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL28294791 | 0.97 | ACE (0.59) | ACEFOLH1NAALAD2CA1CA2 | |
| SCHEMBL28294788 | 0.97 | ACE (0.59) | ACEFOLH1NAALAD2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12359164-B2 | Process for producing cell culture media | MERCK PATENT GMBH (DE) | 2025-07-15 | — | — | US | claimed |
| US-20210207079-A1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2021-07-08 | — | — | US | claimed |
| EP-3331986-B1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2020-07-01 | — | — | EP | claimed |
| US-20180223250-A1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2018-08-09 | — | — | US | claimed |
| EP-3331986-A1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | Merck Patent GmbH (DE) | 2018-06-13 | — | — | EP | claimed |
| CN-104447946-B | A kind of novel crystal forms of Glycyl-L-tyrosine monohydrate and preparation method thereof | 济南康和医药科技有限公司 | 2017-10-31 | — | — | CN | claimed |
| WO-2017020986-A1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2017-02-09 | — | — | WO | claimed |
| CN-104447946-A | Novel crystal form of N-glycyl tyrosine monohydrate and preparation method of novel crystal form | JINAN KANGHE MEDICAL TECHNOLOGY CO LTD | 2015-03-25 | — | — | CN | claimed |
| US-12359164-B2 | Process for producing cell culture media | MERCK PATENT GMBH (DE) | 2025-07-15 | — | — | US | disclosed |
| CN-114763552-B | Recombinant production method of microbial transglutaminase | 山东大学 | 2024-04-30 | — | — | CN | disclosed |
| CN-114763552-A | Recombinant production method of microbial transglutaminase | 山东大学 | 2022-07-19 | — | — | CN | disclosed |
| US-20210207079-A1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2021-07-08 | — | — | US | disclosed |
| EP-3331986-B1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2020-07-01 | — | — | EP | disclosed |
| US-20180223250-A1 | PROCESS FOR PRODUCING CELL CULTURE MEDIA | MERCK PATENT GMBH (DE) | 2018-08-09 | — | — | US | disclosed |
| CN-104931628-A | Fe3O4-COOH magnetic nano-material modified open tubular column as well as preparation method and application thereof | UNIV SOUTH CHINA NORMAL | 2015-09-23 | — | — | CN | disclosed |
| CN-104447946-A | Novel crystal form of N-glycyl tyrosine monohydrate and preparation method of novel crystal form | JINAN KANGHE MEDICAL TECHNOLOGY CO LTD | 2015-03-25 | — | — | CN | disclosed |
| EP-0348261-B1 | Radiohalogenated compounds for site specific labeling | CYTOGEN CORP (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4966999-A | Radiohalogenated compounds for site specific labeling | CYTOGEN CORPORATION (US) | 1990-10-30 | — | — | US | disclosed |
| EP-0348261-A1 | Radiohalogenated compounds for site specific labeling | CYTOGEN CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |
| WO-1989011876-A1 | RADIOHALOGENATED COMPOUNDS FOR SITE SPECIFIC LABELING | CYTOGEN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |