Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | FLT4 | P35916 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11779143 | 0.85 | CA2 (0.63) | FLT1FLT4KDRCA1CA2 | |
| SCHEMBL30595897 | 0.85 | ALDH1A1 (0.51) | FLT1FLT4KDRCA1CA2 | |
| SCHEMBL2084156 | 0.85 | ALDH1A1 (0.51) | FLT1FLT4KDRCA1CA2 | |
| Hydrochloric Acid SCHEMBL28740577 | 0.84 | ALDH1A1 (0.50) | FLT1FLT4KDRCA1CA2 | |
| Methylene Chloride SCHEMBL28138917 | 0.81 | ALDH1A1 (0.48) | FLT1FLT4KDRCA1CA2 | |
| SCHEMBL10940761 | 0.81 | VCAM1 (0.48) | FLT1FLT4KDRVCAM1ALDH1A1 | |
| SCHEMBL27928641 | 0.80 | ALDH1A1 (0.52) | FLT1FLT4KDRCA1CA2 | |
| SCHEMBL7993462 | 0.78 | ALDH1A1 (0.38) | FLT1FLT4KDRALDH1A1HPGD | |
| SCHEMBL3813276 | 0.78 | VCAM1 (0.50) | CA1CA2CA12CA9VCAM1 | |
| SCHEMBL1059060 | 0.77 | CA12 (0.71) | CA1CA2CA12CA9VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0447421-B1 | PREPARATION OF 2-(CHLORO, BROMO OR NITRO)-4-(ALKYLSULFONYL)BENZOIC ACIDS AND INTERMEDIATES | ZENECA INC (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5157150-A | Preparation of 2-(chloro, bromo or nitro)-4-(alkylsulfonyl)benzoic acids and intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-20 | — | — | US | disclosed |
| EP-0447421-A1 | PREPARATION OF 2-(CHLORO, BROMO OR NITRO)-4-(ALKYLSULFONYL)BENZOIC ACIDS AND INTERMEDIATES. | ICI AMERICA INC (US) | 1991-09-25 | — | — | EP | disclosed |
| US-5008448-A | Preparation of 2-(chloro, bromo or nitro)-4-(alkyl-sulfonyl)benzoic acids and intermediates | ICI AMERICAS INC. (US) | 1991-04-16 | — | — | US | disclosed |
| WO-1990006301-A1 | PREPARATION OF 2-(CHLORO, BROMO OR NITRO)-4-(ALKYLSULFONYL)BENZOIC ACIDS AND INTERMEDIATES | ICI AMERICAS INC. (US) | 1990-06-14 | — | — | WO | disclosed |