Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517314 | 0.91 | P4HTM (0.36) | EGFRP4HTMSCN9ASCN5ACASP3 | |
| SCHEMBL9515607 | 0.90 | EPHX2 (0.40) | P4HTMCASP3GABRA5EPHX2 | |
| SCHEMBL9517937 | 0.89 | EGFR (0.40) | EGFRP4HTMSCN9ASCN5ACASP3 | |
| SCHEMBL9517222 | 0.88 | TRPM8 (0.38) | P4HTMSCN9ASCN5ACASP3EPHX2 | |
| SCHEMBL9517963 | 0.87 | TLR4 (0.38) | SMN1; SMN2GABRA5 | |
| SCHEMBL9516974 | 0.86 | EGFR (0.44) | EGFRP4HTMCASP3FLT1FLT4 | |
| SCHEMBL9515729 | 0.84 | BCL2L1 (0.40) | EGFRP4HTMSCN9ASCN5ACASP3 | |
| SCHEMBL9519643 | 0.83 | GRM5 (0.39) | P4HTMCASP3GABRA5 | |
| SCHEMBL9517265 | 0.82 | EGFR (0.41) | EGFRP4HTMSCN9ASCN5ASMN1; SMN2 | |
| SCHEMBL9519634 | 0.81 | HDAC1 (0.39) | CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |