Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9517875 | 1.00 | KMT2A (0.51) | KMT2AMTNR1ATDP1KDM4EALDH1A1 | |
| SCHEMBL10484309 | 0.93 | SIGMAR1 (0.49) | KMT2AMTNR1ASIGMAR1 | |
| Cadaverine Tartrate SCHEMBL9518009 | 0.91 | MTNR1A (0.45) | KMT2AMTNR1ATDP1SIGMAR1MCL1 | |
| Cadaverine Tartrate SCHEMBL9518010 | 0.91 | MTNR1A (0.45) | KMT2AMTNR1ATDP1SIGMAR1MCL1 | |
| Phosphoric Acid SCHEMBL9519019 | 0.83 | ACP3 (0.47) | KMT2AMTNR1ATDP1SIGMAR1OPRD1 | |
| Phosphoric Acid SCHEMBL9519025 | 0.83 | ACP3 (0.47) | KMT2AMTNR1ATDP1SIGMAR1OPRD1 | |
| Hydrochloric Acid SCHEMBL9520766 | 0.82 | MC4R (0.47) | MTNR1ASIGMAR1 | |
| Oxalic Acid SCHEMBL9517855 | 0.80 | KMT2A (0.48) | KMT2AMTNR1ATDP1KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL9517848 | 0.80 | KMT2A (0.48) | KMT2AMTNR1ATDP1KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL9519026 | 0.80 | OPRM1 (0.48) | KMT2AMTNR1ATDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | claimed |
| EP-0318234-B1 | IMPROVEMENTS IN OR RELATING TO SELECTIVE SEROTONIN UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0318234-A2 | Improvements in or relating to selective serotonin uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |