Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL9518009 | 1.00 | MTNR1A (0.45) | MTNR1AKMT2ASIGMAR1METAP2LMNA | |
| Oxalic Acid SCHEMBL9517878 | 0.91 | KMT2A (0.51) | MTNR1AKMT2ASIGMAR1LMNAMCL1 | |
| Oxalic Acid SCHEMBL9517875 | 0.91 | KMT2A (0.51) | MTNR1AKMT2ASIGMAR1LMNAMCL1 | |
| SCHEMBL10484309 | 0.90 | SIGMAR1 (0.49) | MTNR1AKMT2ASIGMAR1 | |
| Cadaverine Tartrate SCHEMBL9518089 | 0.81 | METAP2 (0.47) | MTNR1AKMT2ASIGMAR1METAP2LMNA | |
| Cadaverine Tartrate SCHEMBL9518091 | 0.81 | METAP2 (0.47) | MTNR1AKMT2ASIGMAR1METAP2LMNA | |
| Phosphoric Acid SCHEMBL9519025 | 0.80 | ACP3 (0.47) | MTNR1AKMT2ASIGMAR1LMNATDP1 | |
| Phosphoric Acid SCHEMBL9519019 | 0.80 | ACP3 (0.47) | MTNR1AKMT2ASIGMAR1LMNATDP1 | |
| Hydrochloric Acid SCHEMBL9520766 | 0.79 | MC4R (0.47) | MTNR1ASIGMAR1 | |
| Cadaverine Tartrate SCHEMBL9517398 | 0.78 | METAP2 (0.46) | MTNR1AKMT2ASIGMAR1METAP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318234-B1 | IMPROVEMENTS IN OR RELATING TO SELECTIVE SEROTONIN UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0318234-A2 | Improvements in or relating to selective serotonin uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |