Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.59 |
| ▸ | EGFR | P00533 | 5/20 | 0.59 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519310 | 0.87 | EGFR (0.51) | PTGS2EGFRP4HTMPTGS1ALDH1A1 | |
| SCHEMBL9517200 | 0.86 | P4HTM (0.70) | PTGS2EGFRP4HTMPTGS1ALKBH2 | |
| SCHEMBL9519106 | 0.86 | EGFR (0.50) | PTGS2EGFRP4HTMPTGS1FLT1 | |
| SCHEMBL9518006 | 0.86 | P4HTM (0.67) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9519654 | 0.85 | CA1 (0.51) | EGFRP4HTMKMT2A | |
| SCHEMBL9517944 | 0.85 | EGFR (0.49) | PTGS2EGFRP4HTMALDH1A1FLT1 | |
| SCHEMBL9518008 | 0.85 | P4HTM (0.54) | EGFRP4HTMALDH1A1KMT2A | |
| SCHEMBL9516083 | 0.85 | P4HTM (0.60) | PTGS2EGFRP4HTMPTGS1FLT1 | |
| SCHEMBL9515549 | 0.84 | KDM4E (0.52) | PTGS2EGFRP4HTMALDH1A1FLT1 | |
| SCHEMBL9515565 | 0.83 | BCL2L1 (0.53) | EGFRP4HTMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |