Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514907 | 0.88 | ALB (0.48) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9516865 | 0.79 | HDAC1 (0.42) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5780476 | 0.79 | ALB (0.74) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9516871 | 0.78 | ALDH1A1 (0.45) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7478870 | 0.76 | NR1H4 (0.52) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7478874 | 0.76 | NR1H4 (0.52) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL10352164 | 0.74 | MAPT (0.62) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9514548 | 0.74 | ALOX5 (0.51) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9514540 | 0.74 | ALOX5 (0.51) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL10721799 | 0.73 | GSTO1 (0.40) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219436-B1 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI CHEM IND (JP) | 1993-12-22 | — | — | EP | disclosed |
| US-4902700-A | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1990-02-20 | — | — | US | disclosed |
| EP-0219436-A2 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1987-04-22 | — | — | EP | disclosed |