SCHEMBL951828

SCHEMBL951828

O=C(O)c1cc(OC(F)(F)C(F)OC(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 2/20 0.36
TRPA1 O75762 6/20 0.34
TRPV1 Q8NER1 2/20 0.34
GCK P35557 2/20 0.32
KCNH2 Q12809 1/20 0.31
NTRK1 P04629 1/20 0.31
KMO O15229 1/20 0.30
SLC16A3 O15427 1/20 0.30
SLC16A1 P53985 1/20 0.30
P2RY1 P47900 1/20 0.30
RARG P13631 1/20 0.30
RORC P51449 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12912301 0.91 MALT1 (0.35) MALT1TRPA1TRPV1GCKP2RY1
SCHEMBL951013 0.89 MALT1 (0.36) MALT1TRPA1TRPV1P2RY1RORC
SCHEMBL29185098 0.88 TRPA1 (0.35) MALT1TRPA1TRPV1GCKKCNH2
SCHEMBL12528906 0.82 MALT1 (0.34) MALT1TRPA1TRPV1GCK
SCHEMBL29185079 0.82 TRPA1 (0.35) MALT1TRPA1TRPV1GCKKCNH2
SCHEMBL14658366 0.81 TRPA1 (0.36) MALT1TRPA1TRPV1NTRK1SLC16A3
SCHEMBL16014740 0.81 NPC1 (0.37) MALT1TRPA1TRPV1GCKKCNH2
SCHEMBL27962696 0.80 ALDH1A1 (0.40) MALT1TRPA1TRPV1GCKSLC16A3
SCHEMBL16014767 0.79 TRPA1 (0.36) MALT1TRPA1TRPV1GCKKCNH2
SCHEMBL14658369 0.79 GCK (0.34) MALT1TRPA1TRPV1GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 MALT1 4856/4885TRPA1 437/4885TRPV1 1056/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT MALT1 4865/4885TRPA1 359/4885TRPV1 687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.