SCHEMBL12528906

SCHEMBL12528906

COC(F)C(F)(F)Oc1cc(C(C)=O)n(-c2ncccc2Cl)n1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 6/20 0.34
TRPA1 O75762 5/20 0.34
TRPV1 Q8NER1 2/20 0.34
DHODH Q02127 1/20 0.32
RBP4 P02753 2/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GCK P35557 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12912301 0.91 MALT1 (0.35) MALT1TRPA1TRPV1DHODHGRIN1
SCHEMBL951013 0.85 MALT1 (0.36) MALT1TRPA1TRPV1DHODHRBP4
SCHEMBL29185078 0.83 MALT1 (0.35) MALT1TRPA1TRPV1DHODHRBP4
SCHEMBL951828 0.82 MALT1 (0.36) MALT1TRPA1TRPV1GCK
SCHEMBL29185098 0.80 TRPA1 (0.35) MALT1TRPA1TRPV1DHODHRBP4
SCHEMBL24949786 0.79 TRPA1 (0.36) MALT1TRPA1TRPV1DHODHRBP4
SCHEMBL12528135 0.78 DHODH (0.30) MALT1DHODH
SCHEMBL29185087 0.77 MALT1 (0.35) MALT1TRPA1TRPV1DHODHRBP4
SCHEMBL354326 0.76 KDM4E (0.45) TRPA1TRPV1GRIN1GRIN2A
SCHEMBL17417244 0.75 ALDH1A1 (0.37) MALT1RBP4GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 MALT1 4856/4885TRPA1 437/4885TRPV1 1056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.