Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.51 |
| ▸ | GCGR | P47871 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750959 | 0.82 | ABCB1 (0.49) | HMGCRALDH1A1MEN1GLAMAPT | |
| SCHEMBL9750852 | 0.81 | HMGCR (0.53) | HMGCRALDH1A1MEN1MAPTHPGD | |
| SCHEMBL9750837 | 0.77 | HMGCR (0.58) | HMGCRALDH1A1MAPTABCB1TDP1 | |
| SCHEMBL8846389 | 0.77 | HMGCR (0.55) | HMGCRALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL9518177 | 0.77 | HMGCR (0.47) | HMGCRGCGR | |
| SCHEMBL9024945 | 0.76 | ELAVL1 (0.44) | HMGCRL3MBTL1 | |
| SCHEMBL9750809 | 0.76 | HMGCR (0.68) | HMGCR | |
| SCHEMBL9518809 | 0.75 | HMGCR (0.43) | HMGCRABCB1 | |
| SCHEMBL9750901 | 0.75 | HMGCR (0.53) | HMGCR | |
| SCHEMBL9750841 | 0.74 | HMGCR (0.48) | HMGCRALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |