Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PTAFR | P25105 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519757 | 1.00 | CES2 (0.51) | CES2CES1MTNR1AMTNR1BPARP1 | |
| SCHEMBL9522756 | 0.97 | MTNR1A (0.55) | CES2CES1MTNR1AMTNR1BPARP1 | |
| SCHEMBL9519841 | 0.97 | MTNR1A (0.55) | CES2CES1MTNR1AMTNR1BPARP1 | |
| SCHEMBL9520665 | 0.93 | NPC1 (0.54) | CES2CES1MTNR1AMTNR1BPARP1 | |
| SCHEMBL9519518 | 0.93 | NPC1 (0.54) | CES2CES1MTNR1AMTNR1BPARP1 | |
| SCHEMBL9522407 | 0.84 | CES2 (0.53) | CES2CES1PARP1GPR52NPC1 | |
| SCHEMBL9523136 | 0.84 | CES2 (0.53) | CES2CES1PARP1GPR52NPC1 | |
| SCHEMBL9521346 | 0.82 | CA1 (0.49) | CES2CES1PARP1GPR52NPC1 | |
| SCHEMBL9521201 | 0.81 | TAS1R3 (0.44) | CES2CES1MTNR1AMTNR1BPARP1 | |
| SCHEMBL9520878 | 0.81 | TAS1R3 (0.44) | CES2CES1MTNR1AMTNR1BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |