Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195204 | 0.90 | CA12 (0.40) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL9520618 | 0.90 | POLB (0.40) | ALDH1A1MAPTHPGDTDP1CYP19A1 | |
| SCHEMBL195205 | 0.90 | CA12 (0.40) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL9520501 | 0.88 | ALDH1A1 (0.38) | ALDH1A1MAPTHPGDTDP1CYP19A1 | |
| SCHEMBL9519207 | 0.87 | CYP19A1 (0.37) | ALDH1A1MAPTHPGDTDP1CYP19A1 | |
| SCHEMBL9519151 | 0.86 | ALDH1A1 (0.37) | ALDH1A1MAPTHPGDTDP1CYP19A1 | |
| SCHEMBL8759638 | 0.83 | TDP1 (0.43) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL10364355 | 0.83 | TDP1 (0.43) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL6398540 | 0.83 | TDP1 (0.43) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL10701278 | 0.83 | CCR5 (0.37) | ALDH1A1MAPTHPGDTDP1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280771-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-5061804-A | 3-thiopyrrolidine as chemical intermediates | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4963543-A | BACTERICIDES, TREATING INFECTIOUS DISEASES; THIENAMYCINS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-10-16 | — | — | US | disclosed |
| EP-0280771-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |