Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.56 |
| ▸ | RXRB | P28702 | 3/20 | 0.56 |
| ▸ | RXRG | P48443 | 3/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.55 |
| ▸ | MALT1 | Q9UDY8 | 10/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | RPA1 | P27694 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387633 | 0.84 | PTGS2 (0.69) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9466921 | 0.80 | CNR2 (0.51) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL5416591 | 0.80 | PTGS2 (0.60) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9466275 | 0.77 | ALOX5 (0.50) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9465902 | 0.75 | CNR2 (0.46) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9466137 | 0.75 | CNR2 (0.46) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9520914 | 0.73 | CCKAR (0.61) | RXRARXRBRXRGPTGS2CA1 | |
| SCHEMBL3237716 | 0.73 | CNR2 (0.45) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9519044 | 0.72 | PTGS2 (0.66) | RXRARXRBRXRGMALT1PTGS2 | |
| SCHEMBL9520376 | 0.72 | PTGS2 (0.66) | RXRARXRBRXRGMALT1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | claimed |
| US-4826868-A | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-02 | — | — | US | claimed |
| EP-0248594-A2 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-09 | — | — | EP | claimed |
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5164381-A | Cardiovascular, antiinflammatory | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| US-4826868-A | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0248594-A2 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-09 | — | — | EP | disclosed |