Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.69 |
| ▸ | CCKAR | P32238 | 10/20 | 0.61 |
| ▸ | RXRA | P19793 | 2/20 | 0.60 |
| ▸ | RXRB | P28702 | 2/20 | 0.60 |
| ▸ | RXRG | P48443 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520914 | 0.89 | CCKAR (0.61) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9519044 | 0.88 | PTGS2 (0.66) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9520376 | 0.88 | PTGS2 (0.66) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9081722 | 0.88 | CA1 (0.69) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9519303 | 0.88 | PTGS2 (0.65) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9519309 | 0.86 | PTGS2 (0.63) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9519155 | 0.86 | PTGS2 (0.68) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9519128 | 0.85 | PTGS2 (0.57) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9522506 | 0.85 | PTGS2 (0.67) | PTGS2ALOX5CCKARRXRARXRB | |
| SCHEMBL9520169 | 0.84 | RXRA (0.56) | PTGS2ALOX5RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | claimed |
| US-5164381-A | Cardiovascular, antiinflammatory | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | claimed |
| US-4826868-A | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-02 | — | — | US | claimed |
| EP-0248594-A2 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-09 | — | — | EP | claimed |
| US-7247745-B2 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1413575-B1 | Process for preparing derivatives of ¬(1,5-diaryl)pyrazol-3-yl|propanoic acid | ORTHO MCNEIL PHARM INC (US) | 2006-10-11 | — | — | EP | disclosed |
| US-20060004208-A1 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ABDEL-MAGID AHMED F | 2006-01-05 | — | — | US | disclosed |
| US-6953860-B2 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ABDEL-MAGID AHMED F | 2005-10-11 | — | — | US | disclosed |
| EP-1413575-A9 | Process for preparing derivatives of [(1,5-diaryl)pyrazol-3-yl]propanoic acid | Ortho-McNeil Pharmaceutical, Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040230060-A1 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ABDEL-MAGID AHMED F (US) | 2004-11-18 | — | — | US | disclosed |
| EP-1144382-B1 | PROCESS FOR PREPARING 1,5-DIARYL-3-SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARM INC (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-1413575-A2 | Process for preparing derivatives of [(1,5-diaryl)pyrazol-3-yl]propanoic acid | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6384233-B1 | PHENYL KETONE DERIVATIVE REACTED WITH SUCCINIC ANHYDRIDE ANDPOTASSIUM T-BUTOXIDE, DIKETONE PRODUCT REACTED WITH HYDRAZINE DERIVATIVE TO CAUSE CYCLIZATION, ESTERIFICATION WITH ETHANOL AND REACTING WITH N-METHYLHYDROXYLAMINE HYDROCHLORIDE | ABDEL-MAGID AHMED F (US) | 2002-05-07 | — | — | US | disclosed |
| US-20020032336-A1 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ABDEL-MAGID AHMED F (US) | 2002-03-14 | — | — | US | disclosed |
| EP-1144382-A2 | PROCESS FOR PREPARING 1,5-DIARYL-3-SUBSTITUTED PYRAZOLES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001009102-A2 | PROCESS FOR PREPARING 1,5-DIARYL-3-SUBSTITUTED PYRAZOLES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-02-08 | — | — | WO | disclosed |
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5164381-A | Cardiovascular, antiinflammatory | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| US-4826868-A | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0248594-A2 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004208-A1 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ADH5, ADH1C, ADH1A | PTGS2 1186/4885ALOX5 533/4885CCKAR 2993/4885 |
| US-20040230060-A1 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ADH5, ADH1C, ADH1A | PTGS2 1114/4885ALOX5 670/4885CCKAR 3391/4885 |
| US-20020032336-A1 | Process for preparing 1,5-diaryl-3-substituted pyrazoles | ADH5, ADH1C, ADH1A | PTGS2 1114/4885ALOX5 670/4885CCKAR 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.