Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | RPA1 | P27694 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | CCKAR | P32238 | 3/20 | 0.52 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749563 | 0.91 | PTGS2 (0.73) | PTGS2ALOX5CHRNA7RPA1PTGS1 | |
| SCHEMBL9520508 | 0.84 | ALOX5 (0.83) | PTGS2ALOX5PTGS1CCKAR | |
| SCHEMBL9350647 | 0.81 | CA9 (0.71) | CHRNA7RPA1CCKARMALT1 | |
| SCHEMBL9349395 | 0.80 | RPA1 (0.64) | CHRNA7RPA1CCKARMALT1 | |
| SCHEMBL8475502 | 0.79 | MALT1 (0.68) | PTGS2ALOX5CHRNA7RPA1PTGS1 | |
| SCHEMBL9054421 | 0.78 | CA9 (0.65) | PTGS2CHRNA7RPA1MALT1 | |
| SCHEMBL9349936 | 0.77 | RPA1 (0.70) | CHRNA7RPA1CCKARMALT1 | |
| SCHEMBL9349904 | 0.77 | RPA1 (0.49) | PTGS2ALOX5RPA1CCKARMALT1 | |
| SCHEMBL9349431 | 0.77 | RPA1 (0.49) | PTGS2ALOX5RPA1CCKARMALT1 | |
| SCHEMBL9056282 | 0.76 | RPA1 (0.90) | CHRNA7RPA1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380869-A | Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-01-10 | — | — | US | disclosed |
| US-5260458-A | 2-oxo tetrahydrofuran compounds | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0534800-A2 | Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5117054-A | Chemical intermediate for antiinflammatory agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |