Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL579843 | 0.82 | SIGMAR1 (0.43) | SIGMAR1 | |
| SCHEMBL580340 | 0.81 | HTR2A (0.40) | — | |
| SCHEMBL9520669 | 0.77 | SIGMAR1 (0.51) | POLBALDH1A1SIGMAR1MEN1KMT2A | |
| SCHEMBL5666026 | 0.76 | MEN1 (0.50) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11676878 | 0.74 | GAA (0.44) | POLBMEN1KMT2AMAPT | |
| SCHEMBL9520915 | 0.72 | HTR2A (0.39) | ALDH1A1SIGMAR1KMT2AMAPT | |
| SCHEMBL9521674 | 0.72 | SIGMAR1 (0.58) | SIGMAR1 | |
| SCHEMBL11255464 | 0.71 | POLB (0.49) | POLBALDH1A1SMN1; SMN2SIGMAR1MEN1 | |
| SCHEMBL5664114 | 0.71 | MTNR1B (0.58) | POLB | |
| SCHEMBL11777003 | 0.71 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |