Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513750 | 0.88 | HDAC3 (0.46) | HDAC3HDAC1PTGS1PTGS2HSD17B10 | |
| SCHEMBL9515169 | 0.87 | MAPT (0.51) | HDAC3HDAC1LMNAHSD17B10KDM4E | |
| SCHEMBL9658888 | 0.85 | HDAC3 (0.48) | HDAC3HDAC1PTGS1PTGS2LMNA | |
| SCHEMBL9513635 | 0.73 | MAPT (0.61) | LMNAHSD17B10MAPTKMT2AHTR1A | |
| SCHEMBL9517325 | 0.68 | LMNA (0.41) | LMNAMAPTKMT2AHTR1AHTR2A | |
| SCHEMBL9513853 | 0.67 | SMN1; SMN2 (0.49) | LMNAMAPTKMT2AHTR1AHTR2A | |
| SCHEMBL9514774 | 0.67 | HTR1A (0.42) | LMNAMAPTKMT2AHTR1AHTR2A | |
| SCHEMBL9514297 | 0.66 | HTR1A (0.39) | LMNAMAPTHTR4KMT2AHTR1A | |
| SCHEMBL9514753 | 0.66 | HTR1A (0.45) | LMNAMAPTKMT2AHTR1AHTR2A | |
| SCHEMBL28408669 | 0.66 | PTGS1 (0.74) | PTGS1PTGS2HSD17B10KDM4ETRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |