Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | HTR7 | P34969 | 7/20 | 0.39 |
| ▸ | HTR6 | P50406 | 7/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514774 | 0.90 | HTR1A (0.42) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9513853 | 0.84 | SMN1; SMN2 (0.49) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9513635 | 0.81 | MAPT (0.61) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9517325 | 0.80 | LMNA (0.41) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9514753 | 0.78 | HTR1A (0.45) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9513807 | 0.76 | MEN1 (0.38) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL9280115 | 0.74 | HTR1A (0.52) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9515163 | 0.74 | STAT3 (0.40) | HTR1AMAPTSMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL9517218 | 0.73 | HTR1A (0.42) | HTR1AMAPTMEN1LMNAKMT2A | |
| SCHEMBL9516852 | 0.71 | MAPT (0.40) | MAPTMEN1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |