Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 13/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514753 | 0.91 | HTR1A (0.45) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9517236 | 0.85 | HTR1A (0.43) | MAPTHTR1AHTR2ADRD2HTR7 | |
| SCHEMBL9513635 | 0.84 | MAPT (0.61) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9513853 | 0.83 | SMN1; SMN2 (0.49) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9515127 | 0.83 | LMNA (0.41) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9514774 | 0.81 | HTR1A (0.42) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9514297 | 0.80 | HTR1A (0.39) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9514280 | 0.77 | HTR1A (0.44) | HTR1A | |
| SCHEMBL9228149 | 0.75 | HTR1A (0.50) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9513686 | 0.74 | SIGMAR1 (0.47) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |