Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | HTR7 | P34969 | 6/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514297 | 0.90 | HTR1A (0.39) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9513807 | 0.86 | MEN1 (0.38) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL9513853 | 0.86 | SMN1; SMN2 (0.49) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9280115 | 0.85 | HTR1A (0.52) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9515163 | 0.84 | STAT3 (0.40) | HTR1AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9517218 | 0.83 | HTR1A (0.42) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9513635 | 0.83 | MAPT (0.61) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9517325 | 0.81 | LMNA (0.41) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9514753 | 0.79 | HTR1A (0.45) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9513786 | 0.78 | NPC1 (0.48) | HTR1AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |