Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525735 | 0.86 | EGLN1 (0.49) | HSP90AA1KMT2ASMN1; SMN2L3MBTL1EGLN1 | |
| SCHEMBL9523469 | 0.82 | EGLN1 (0.45) | HSP90AA1KMT2ASMN1; SMN2L3MBTL1EGLN1 | |
| SCHEMBL9525718 | 0.82 | TP53 (0.47) | HSP90AA1KMT2AEGLN1BBOX1FTO | |
| SCHEMBL9524703 | 0.81 | GPR27 (0.46) | HSP90AA1KMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9527385 | 0.79 | MEN1 (0.52) | KMT2AMAPTMEN1ALDH1A1POLB | |
| SCHEMBL9527944 | 0.77 | NSD2 (0.50) | KMT2AL3MBTL1ADORA2AMAPTKDM4E | |
| SCHEMBL9523503 | 0.75 | KCNMA1 (0.50) | KMT2ASMN1; SMN2MEN1TP53PKM | |
| SCHEMBL9524520 | 0.72 | LMNA (0.51) | KMT2ASMN1; SMN2L3MBTL1MAPTKDM4E | |
| SCHEMBL9524641 | 0.72 | ALDH1A1 (0.45) | KMT2ASMN1; SMN2ADORA2AMAPTPTGER4 | |
| SCHEMBL9524438 | 0.72 | MEN1 (0.50) | KMT2AADORA2AMEN1TP53MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |